Perilla frutescens
Perilla
Generally recognised as safeOther names: Beefsteak plant
Shiso / egoma—widely in Japanese cuisine and cultivation.
Square stem; often crisped aromatic leaves.
- Family
- Lamiaceae
- Plant type
- Annual / perennial herb
What the safety levels mean (expand legend)
- Generally recognised as safe. Often a common herb with reasonable harvest and use; still read the specific warnings on the card.
- Information. Primarily informational — details in the text and warnings below matter most.
- Caution. Needs extra care (dose, duration, sensitive groups, interactions).
- Risky. Significant risks — verify sources, contraindications and professional guidance.
- Not for home experimentation. Not suitable to experiment with at home without knowledge and certainty.
- High risk for internal use. Particular risk with internal use (e.g. alkaloids); avoid prolonged or irresponsible dosing.
- Not specified. Level not filled in yet — rely on individual warnings and links below.

Photograph on Wikimedia Commons (CC BY-SA 3.0).
Plant habit
Quick overview
A practical summary; details are in the sections below.
- Safety grade
- Generally recognised as safe details
- Scientific sources on the card
- Yes — sources are listed with claims Science section
- When and what to harvest
- Leaf — June–September
- Fruit — October–November
- Processing methods
Herbal vinegar, Culinary use, Herbal oil
All methods and recipes on the card- Topics and symptoms
Common cold — overall comfort, Seasonal allergies
Topics section, Symptoms overview
Identification and mix-ups
Spicate inflorescence; leaf colours vary by form.
Possible mix-ups and risks
Basil and mints by scent and habit.
Similar herbs
- Sweet basil
Both mint-family plants of similar habit; shiso has broader, toothed, crinkled leaves with a scent between mint, basil and cinnamon. Basil is smooth and aniseed-like.
Topics and symptoms
More topics are in the symptoms and topics overview.
- Common cold — overall comfortTraditional· Traditional / cultural framing
- Seasonal allergiesTraditional· Traditional / cultural framing
Geographic occurrence
Japan
Common (expected wild occurrence in the region)
Harvest
- LeafJune–September
léto
Region: JapanNotes: Leaves are picked from early summer until flowering; green shiso (aojiso) as a herb, red (akajiso) mainly for pickling umeboshi in June and July. Flower spikes (hojiso) are cut just after opening.
- FruitOctober–November
podzim
Region: JapanNotes: Seeds (egoma) are harvested in autumn as the spikes brown; they are dried and pressed for oil or roasted and ground into sauces.
Storage
- Refrigeration(Leaf)
Fresh leaves keep 3–5 days in the fridge with stalks in water under a bag; otherwise they wilt within a day.
- Moisture:
- Wet leaves blacken.
- Airtight storage(Fruit)
Seed oil (egoma-abura) is rich in alpha-linolenic acid and turns rancid fast: refrigerate once opened and use within 1–2 months, never heat it.
- Light:
- Dark bottle, out of light.
- Safety:
- Discard rancid oil (fishy smell).
Processing methods on this herb card
Maceration or extraction in vinegar; acidity changes flavour and extraction.
Full method description (from the catalogue)
Herbal vinegar uses acetic acid as part of the solvent. You get different flavours and sometimes different stability than with alcohol or water. Vinegars are used culinarily and as bases for traditional oxymels per recipe.
Vinegar quality (food grade, known origin) matters; metal vessels can react — prefer glass or stainless steel.
Traditional context for this method: yes·Scientific context for this method: no
Cooking, baking, seasoning as food — general category without therapeutic claims.
Full method description (from the catalogue)
Culinary use covers herbs as ingredients in dishes, drinks, or spice mixes. This overview does not evaluate medicinal effects — only reminds you about species intent, allergies, and heat treatment where needed (e.g. some fruits or plant parts).
Combining with alcohol, sugar, or long cooking changes outcomes; verify culinary sources.
Traditional context for this method: yes·Scientific context for this method: no
Macerating herbs in a vegetable oil (cold or with gentle heat).
Full method description (from the catalogue)
Herbal oil is made by steeping dried or fresh material in oil (e.g. olive, sunflower) over time, sometimes with gentle warming. The result is not steam-distilled essential oil — it is a different extract type and usage (often topical or culinary per recipe).
Temperature, light, and material moisture affect shelf life; rancid oil must be discarded.
Traditional context for this method: yes·Scientific context for this method: no
Pressed seed oil (egoma) only cold and for salads; heating and rancidity break down the omega-3 acids.
Traditional / spiritual use
Kept separate from science — entries are cultural or symbolic, not medical advice.
Zi su — 'the purple leaf that revives'
General
Historical mentionHerbal loreMythologyThe Chinese name zi su (紫蘇, Japanese shiso) means 'purple revival': legend has the physician Hua Tuo (2nd–3rd century) save a youth poisoned by crabs with a decoction of purple leaves, whence the custom of serving shiso with raw fish and crab that continues in Japan today. A historical tale, not evidence of effect.
- Form:
- list k syrové rybě, legenda o názvu
- Claim strength:
- Historical mention
- Source note:
- Chinese medical legend of Hua Tuo; Japanese culinary tradition (shiso with sashimi).
Scientific notes
Each claim lists a study type and a source (URL or DOI) where available. Dose notes from the literature are informational only.
How to read evidence strength and study type labels
Labels summarise how the catalogue entry is tagged — they are not a medical verdict on efficacy. For every row, read the summary, limitations and source link.
Evidence strength
- Evidence level not specified
- The author did not grade the record; judge from the summary, limitations and source link.
- Narrative / orientational literature
- Descriptive or expert literature without controlled group comparison — context rather than proof of effect.
- Weak evidence
- Study or conclusion with major methodological limits; treat only as a pointer for further reading.
- Preliminary findings
- First or smaller studies — interesting direction, not the final word on efficacy or safety.
- Moderate strength of evidence
- Moderate strength by study design; sample and context limits still apply.
- Stronger evidence
- Stronger design or consistency of results within the study's stated limits.
- Review article
- A review summarises multiple sources; quality depends on review method and field.
Study type
- Narrative / expert text
- Expert text or overview without a classical study design.
- In vitro study
- Cell culture or test-tube experiment — does not show an effect in the body.
- Animal study
- Animal model — transfer to humans is not automatic.
- Observational study
- Observing groups without random treatment assignment; confounding is possible.
- Clinical trial
- Human clinical trial; sample size and control group matter.
- Randomised controlled trial
- Randomised controlled trials are among the stronger designs when well conducted.
- Review study
- A review aggregates multiple papers — quality depends on selection rules.
- Systematic review
- Systematic review with explicit search and selection methodology.
- Meta-analysis
- Statistical pooling of studies; outcome depends on input data and heterogeneity.
- Regulatory assessment / monograph (EMA, WHO…)
- Regulatory body summary for a herbal product — different context from a single RCT; often about products, not home tea.
- Expert monograph (herbal preparations)
- Structured literature summary for a plant or drug — quality depends on author and edition year.
The review summarises the traditional use of perilla in Chinese, Japanese and Korean medicine (colds, cough, allergy, seafood 'poisoning') and laboratory studies of anti-allergic, anti-inflammatory and antioxidant actions of leaf extracts and of the alpha-linolenic-acid-rich seed oil.
Narrative / orientational literatureReview studyYear: 2018Limitations: Mostly in vitro and animal studies; human clinical data are scarce and small. It does not support treatment of allergy.
Ahmed HM — Molecules
Ethnomedicinal, Phytochemical and Pharmacological Investigations of Perilla frutescens (L.) Britt.
Images
The main photo is in the card header. More images will appear here when available.
Safety
What the warning types mean
The type on each warning helps group themes — it does not replace the separate severity badge.
- Internal use
- Risks from swallowing, extracts, duration of use or concentration for internal use.
- Interactions / medicines
- Possible effect on medicines or concurrent treatment — check sources and a professional.
- Raw plant parts
- Raw, unripe or poorly prepared plant parts can be dangerous.
- Toxins and regulation
- Toxic constituents or regulated compounds (e.g. in distillates).
- Contact with the plant
- Skin or mucosa irritation from contact with fresh plant or sap.
- Allergy
- Allergic reactions, often linked to family sensitisation.
- Harvesting and contamination
- Contamination, species mix-ups or harvesting from unsuitable places.
No structured safety records yet.